Description

Pro-Resolving mediators (PRMs) are the end products of the body’s metabolism of EPA and DHA. Thorne’s Pro-Resolving Mediators supplement includes the precursors the body needs to create pro-resolving mediators – two pre-resolving mediators 17-HDHA and 14-HDHA from DHA and one pre-resolving mediator 18-HEPE from EPA, as well as their parents EPA and DHA, to deliver a one-two punch in support of a balanced inflammatory response. A balanced inflammatory response helps bring the body back into homeostasis after an injury or other insult – essentially helping to “resolve” the problem.* In fact, groups of PRMs produced in the body are called resolvins and protectins – basically members of the body’s “cleanup crew.”

 

Benefits of Thorne’s Pro-Resolving Mediators

  • Provides support for healthy brain structure and cognitive function*
  • Helps maintain a balanced immune/inflammatory response throughout the body*
  • Promotes clearance of cellular debris – the dead cells and byproducts of the inflammatory process*
  • Supports exercise recovery*

 

Features of Thorne's Pro-Resolving Mediators

  • Includes EPA and DHA in addition to three pre-resolving mediators
  • Contains an omega-3 blend with the highest concentration of pre-resolving mediators on the market

Suggested Use:

Take 1 gelcap daily or as recommended by your health-care practitioner.

Warnings:

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

The omega-3 fatty acids in Pro-Resolving Mediators are derived from fish and/or shellfish.

PREGNANCY

If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS

There are no known adverse interactions or contraindications at publication date.

FAQs
Frequently asked question

Is Pro-Resolving Mediators worth buying compared to a regular fish oil supplement?

Pro-Resolving Mediators goes beyond standard fish oil by including pre-resolving mediators 17-HDHA, 14-HDHA, and 18-HEPE alongside EPA and DHA. Regular fish oil only provides the parent fatty acids, leaving your body to do all the conversion work. This supplement delivers the precursors your body needs more directly, making it a more targeted option for those specifically seeking support for a balanced inflammatory response.

Where can I buy Thorne's Pro-Resolving Mediators and is it available for subscription?

Thorne's Pro-Resolving Mediators is available directly on our product page. Purchasing through an authorized retailer ensures you receive a genuine, quality-tested product. Many platforms offer a subscribe-and-save option, which can reduce cost per bottle and ensure you never run out. Buying direct from Thorne also gives you access to customer support and any satisfaction guarantees the brand offers.

What are pro-resolving mediators and why does the body need them?

Pro-resolving mediators (PRMs) are specialized compounds produced when your body metabolizes EPA and DHA omega-3 fatty acids. They play a key role in helping the body actively resolve inflammation rather than simply suppressing it. This process supports tissue recovery and helps return the body to a balanced, healthy state. Without adequate EPA and DHA, your body may struggle to produce sufficient PRMs naturally.

What is the difference between pre-resolving mediators and pro-resolving mediators?

Pre-resolving mediators like 17-HDHA, 14-HDHA, and 18-HEPE are the intermediate compounds your body converts into fully active pro-resolving mediators. Think of them as one step earlier in the production process. Thorne's formula includes both the parent omega-3s (EPA and DHA) and these pre-resolving mediators, giving your body multiple entry points to efficiently produce the final active compounds it needs.

Who should consider taking Pro-Resolving Mediators?

This supplement is well-suited for adults looking to support a healthy inflammatory response, particularly those who are physically active, recovering from exercise, or managing everyday inflammation from lifestyle factors. It may also benefit individuals who don't consistently consume fatty fish or those whose bodies may have difficulty efficiently converting standard omega-3s into active pro-resolving compounds. Always consult your healthcare provider before starting any new supplement.

How long does it take to notice results from Pro-Resolving Mediators?

Results can vary depending on your baseline omega-3 levels, diet, and overall health. Some users report noticing improved recovery and comfort within a few weeks of consistent use. For best results, most experts suggest taking omega-3-based supplements daily for at least 4 to 8 weeks before evaluating their full effect. Pairing the supplement with a balanced diet rich in whole foods may enhance its benefits.

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