Description

Folate is a key component in the body’s methylation cycle, a series of biochemical reactions that play a beneficial role in multiple body systems. Heart and brain health, cellular energy production, fat metabolism, liver detoxification, and bone health all rely on a healthy methylation cycle.

Approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. For these individuals, methylated vitamins, like Thorne’s 5-MTHF, provide essential nutritional support.*


Benefits of Thorne 5-MTHF

  • Nutritional support for individuals who have an MTHFR gene mutation*
  • Supports production of key neurotransmitters – serotonin, melatonin, dopamine, and epinephrine – natural brain chemicals that play an important role in regulating brain function and mood*
  • Promotes cardiovascular, brain, and bone health by maintaining a healthy methylation cycle and a normal homocysteine level*
  • Supports healthy fetal brain and spinal cord development*
  • Promotes blood and nerve cell health*


Features of Thorne 5-MTHF

  • Suitable for individuals who have an MTHFR gene mutation*
  • Active, methylated folate (5-MTHF) means your body gets the highest benefit with the least additional work
  • 1 mg 5-MTHF is recommended for support of fetal development during pregnancy*
  • Easy-to-take, small capsules


This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants, such as heavy metals, pesticides, and microorganisms.

Suggested Use:

Take 1 capsule one to three times daily or as recommended by your health-care practitioner.

Warnings:

ALLERGY WARNING

This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.

PREGNANCY

If pregnant, consult your health-care practitioner before using this product.

INTERACTIONS

5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.

FAQs
Frequently asked question

Is Thorne 5-MTHF 1 mg worth buying if I already take a regular folic acid supplement?

If you have a common genetic variation (MTHFR), your body may struggle to convert regular folic acid into its active form. 5-MTHF is already in the bioavailable, methylated form your body can use immediately. For people with this variation, 5-MTHF is generally considered a more effective choice than standard folic acid supplements. Consult your healthcare provider to determine which option is right for you.

Where can I buy Thorne 5-MTHF 1 mg and is it available directly from Thorne?

Thorne 5-MTHF 1 mg is available directly through Thorne's official website, ensuring product authenticity and quality. It is also sold through select authorized retailers. Purchasing directly from Thorne often provides access to subscription discounts, customer support, and a satisfaction guarantee. Buying from authorized sources protects you from counterfeit or improperly stored products.

What is 5-MTHF and how is it different from regular folate?

5-MTHF (5-methyltetrahydrofolate) is the active, methylated form of folate that your body can use directly. Regular folic acid requires enzymatic conversion before your body can utilize it. About 60% of adults carry a genetic variation that impairs this conversion process, making 5-MTHF a more reliable and efficient option for supporting healthy folate levels.

What does the methylation cycle do and why does it matter for my health?

The methylation cycle is a series of biochemical reactions essential to many body functions, including heart and brain health, cellular energy production, fat metabolism, liver detoxification, and bone health. When methylation is disrupted, these systems can underperform. Supporting the cycle with methylated nutrients like 5-MTHF helps keep these critical processes running smoothly.

How do I know if I have the MTHFR genetic variation that affects folate absorption?

The MTHFR genetic variation is extremely common, affecting approximately 60% of U.S. adults. Genetic testing, available through healthcare providers or direct-to-consumer DNA tests, can confirm whether you carry it. Symptoms like fatigue, brain fog, or elevated homocysteine levels may also suggest impaired methylation. Always consult a healthcare professional for personalized guidance.

What is the recommended dosage for Thorne 5-MTHF 1 mg?

Thorne 5-MTHF 1 mg is formulated as a convenient daily supplement. The typical recommendation is one capsule per day, though individual needs may vary based on health status and genetic factors. Higher-dose versions are also available for those who require additional support. Always follow label directions and consult your healthcare provider before starting any new supplement regimen.

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